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TargetAurora kinase A
LigandBDBM50106629
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1508718 (CHEMBL3602981)
Kd 9.1±n/a nM
Citation Lavogina, D; Kisand, K; Raidaru, G; Uri, A Fluorescent photoaffinity probes for mitotic protein kinase Aurora A. Bioorg Med Chem Lett25:3290-4 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase A
Name:Aurora kinase A
Synonyms:AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:Serine/threonine-protein kinase
Mol. Mass.:45830.98
Organism:Homo sapiens (Human)
Description:O14965
Residue:403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50106629
n/a
NameBDBM50106629
Synonyms:CHEMBL3600762
TypeSmall organic molecule
Emp. Form.C130H174ClFN35O21S3
Mol. Mass.2713.64
SMILESCCN1\C(=C\C=C\C2=[N+](CC)c3ccc(cc3C2(C)C)S(O)(=O)=O)C(C)(CCCC(=O)NCCCC[C@@H](NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)CCCNC(=O)[C@@]2(Cc3cccc(Nc4nccs4)n3)CC[C@@H](CC2)Oc2cccc(Cl)c2F)C(N)=O)c2cc(ccc12)S(O)(=O)=O |r,wU:106.108,73.75,150.155,95.97,51.53,wD:62.64,125.129,84.86,40.42,36.37,166.177,c:7,(-80.23,-12.05,;-79.14,-12.62,;-77.84,-11.79,;-77.75,-10.29,;-78.96,-9.34,;-78.74,-7.81,;-79.95,-6.86,;-79.73,-5.34,;-78.38,-4.64,;-77.02,-5.35,;-76.96,-6.58,;-78.61,-3.13,;-77.63,-1.94,;-78.19,-.49,;-79.71,-.24,;-80.7,-1.45,;-80.13,-2.89,;-80.82,-4.25,;-81.24,-5.41,;-81.59,-3.29,;-80.25,1.2,;-80.68,2.35,;-79.47,2.15,;-81.46,1.4,;-76.28,-9.87,;-75.07,-9.69,;-77.28,-8.71,;-76.78,-7.25,;-75.28,-6.95,;-74.78,-5.49,;-75.6,-4.56,;-73.27,-5.18,;-72.78,-3.72,;-71.27,-3.42,;-70.78,-1.96,;-69.27,-1.65,;-68.78,-.19,;-67.27,.11,;-66.78,1.57,;-67.6,2.5,;-65.27,1.88,;-64.26,.72,;-64.75,-.74,;-63.73,-1.9,;-64.22,-3.35,;-63.21,-4.51,;-62,-4.27,;-63.6,-5.68,;-64.78,3.34,;-63.27,3.64,;-62.46,2.72,;-62.78,5.1,;-63.8,6.25,;-65.31,5.95,;-66.33,7.1,;-67.84,6.79,;-68.86,7.95,;-68.47,9.11,;-70.07,7.7,;-61.27,5.41,;-60.78,6.87,;-61.59,7.79,;-59.27,7.17,;-58.25,6.02,;-56.74,6.33,;-55.72,5.17,;-54.21,5.48,;-53.19,4.33,;-53.58,3.16,;-52.18,4.53,;-58.78,8.63,;-57.27,8.94,;-56.45,8.01,;-56.78,10.4,;-57.79,11.55,;-57.3,13.01,;-58.32,14.17,;-57.82,15.63,;-58.84,16.79,;-60.05,16.54,;-58.51,17.76,;-55.27,10.7,;-54.78,12.16,;-55.59,13.08,;-53.27,12.47,;-52.25,11.31,;-52.74,9.85,;-51.73,8.69,;-52.22,7.23,;-51.2,6.08,;-50,6.32,;-51.53,5.11,;-52.78,13.93,;-51.27,14.23,;-50.45,13.31,;-50.78,15.69,;-51.8,16.84,;-53.31,16.54,;-54.33,17.69,;-55.84,17.38,;-56.86,18.54,;-56.47,19.7,;-57.86,18.33,;-49.27,16,;-48.77,17.46,;-49.59,18.38,;-47.27,17.76,;-46.25,16.6,;-46.74,15.15,;-45.73,13.99,;-46.22,12.53,;-47.73,12.23,;-48.75,13.39,;-48.25,14.85,;-48.23,10.77,;-49.44,10.54,;-47.22,9.61,;-45.71,9.91,;-44.7,8.75,;-45.19,7.3,;-46.7,7,;-47.72,8.16,;-46.77,19.22,;-45.26,19.53,;-44.45,18.6,;-44.77,20.99,;-45.79,22.14,;-45.3,23.6,;-43.79,23.91,;-43.3,25.37,;-44.32,26.52,;-45.83,26.21,;-46.32,24.76,;-43.83,27.98,;-42.62,28.23,;-44.85,29.13,;-44.36,30.59,;-45.38,31.75,;-46.89,31.44,;-47.38,29.98,;-46.36,28.83,;-43.26,21.29,;-42.77,22.75,;-43.45,23.52,;-41.26,23.06,;-40.77,24.52,;-39.26,24.82,;-38.77,26.28,;-37.26,26.59,;-36.45,25.66,;-36.77,28.05,;-35.26,28.35,;-34.24,27.2,;-32.73,27.5,;-31.71,26.34,;-32.21,24.88,;-33.72,24.58,;-34.21,23.12,;-33.19,21.97,;-33.53,20.48,;-32.21,19.7,;-31.06,20.72,;-31.67,22.13,;-34.73,25.74,;-38.25,27.71,;-39.27,28.86,;-38.78,30.32,;-37.27,30.63,;-36.25,29.47,;-39.8,31.48,;-39.31,32.94,;-37.8,33.24,;-37.31,34.7,;-38.33,35.85,;-39.84,35.55,;-40.66,36.47,;-40.33,34.09,;-41.54,33.85,;-69.8,.96,;-69.41,2.13,;-71.01,.71,;-75.45,-11.16,;-73.92,-11.38,;-73.37,-12.84,;-74.33,-14.03,;-75.87,-13.79,;-76.41,-12.35,;-71.85,-13.09,;-71.41,-14.24,;-71.06,-12.14,;-70.63,-13.29,)|
Structure
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