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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM162123
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1509561
Ki 21±n/a nM
Citation Holzer PMasuya KFuret PKallen JValat-Stachyra TFerretti SBerghausen JBouisset-Leonard MBuschmann NPissot-Soldermann CRynn CRuetz SStutz SChène PJeay SGessier F Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. J Med Chem 58:6348-58 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:6.3.2.- | Cdm2 | Double minute 2 protein | E3 ubiquitin-protein ligase Mdm2 | MDM2 | p53-binding protein Mdm2
Type:PROTEIN
Mol. Mass.:54662.03
Organism:Canis lupus familiaris
Description:ChEMBL_109854
Residue:487
Sequence:
MCNTNMSVSTGGAVSTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVIFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQHEPSDSGT
SVSENSCHREGGSDQKDPVQELQEEKPSSSDLISRPSTSSRRRTISETEEHADDLPGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYRVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPPHCNRCWALRENWLPEDKGKIPEKATPENSTQVEEGFDVPDCKK
AAASDSRESCAEEIDDKITQASHSQESEDYSQPSTSNSIIYSSQEDVKEFEREETQDKEE
IVESSFPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQM
IVLTYFP
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  Blast E-value cutoff:
BDBM162123
n/a
NameBDBM162123
Synonyms:US9051279, 106
TypeSmall organic molecule
Emp. Form.C38H47ClN4O4
Mol. Mass.659.257
SMILESCOc1cc2CC(=O)N([C@@H](c3ccc(Cl)cc3)c2cc1OC(C)C)c1ccc(cc1)N(C)C[C@H]1CC[C@@H](CC1)N1CCN(C)C(=O)C1 |r,wU:33.36,wD:9.9,36.43,(8.67,.77,;7.34,1.54,;6,.77,;4.67,1.54,;3.33,.77,;2,1.54,;.67,.77,;-.67,1.54,;.67,-.77,;2,-1.54,;2,-3.08,;.67,-3.85,;.67,-5.39,;2,-6.16,;2,-7.7,;3.33,-5.39,;3.33,-3.85,;3.33,-.77,;4.67,-1.54,;6,-.77,;7.34,-1.54,;7.34,-3.08,;8.67,-3.85,;6,-3.85,;-.67,-1.54,;-2,-.77,;-3.33,-1.54,;-3.33,-3.08,;-2,-3.85,;-.67,-3.08,;-4.67,-3.85,;-4.67,-5.39,;-6,-3.08,;-6,-1.54,;-7.34,-.77,;-7.34,.77,;-6,1.54,;-4.67,.77,;-4.67,-.77,;-6,3.08,;-4.67,3.85,;-4.67,5.39,;-6,6.16,;-6,7.7,;-7.34,5.39,;-8.67,6.16,;-7.34,3.85,)|
Structure
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