| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transthyretin |
|---|
| Ligand | BDBM22971 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1508575 (CHEMBL3602658) |
|---|
| Kd | 480±n/a nM |
|---|
| Citation |  Iakovleva, I; Brännström, K; Nilsson, L; Gharibyan, AL; Begum, A; Anan, I; Walfridsson, M; Sauer-Eriksson, AE; Olofsson, A Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma. J Med Chem58:6507-15 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transthyretin |
|---|
| Name: | Transthyretin |
|---|
| Synonyms: | ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 15884.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P02766 |
|---|
| Residue: | 147 |
|---|
| Sequence: | MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
|
|
|
|---|
| BDBM22971 |
|---|
| n/a |
|---|
| Name | BDBM22971 |
|---|
| Synonyms: | 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid | CHEMBL509 | Meclofenamate | Meclofenamic acid | US11337935, Compound Meclofenamic-acid | US20240002326, Compound Meclofenamic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H11Cl2NO2 |
|---|
| Mol. Mass. | 296.149 |
|---|
| SMILES | Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
