Reaction Details |
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Target | Baculoviral IAP repeat-containing protein 2 |
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Ligand | BDBM156012 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1508698 (CHEMBL3602896) |
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IC50 | 10.0±n/a nM |
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Citation | Chessari, G; Buck, IM; Day, JE; Day, PJ; Iqbal, A; Johnson, CN; Lewis, EJ; Martins, V; Miller, D; Reader, M; Rees, DC; Rich, SJ; Tamanini, E; Vitorino, M; Ward, GA; Williams, PA; Williams, G; Wilsher, NE; Woolford, AJ Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP. J Med Chem58:6574-88 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Baculoviral IAP repeat-containing protein 2 |
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Name: | Baculoviral IAP repeat-containing protein 2 |
Synonyms: | API1 | BIRC2 | BIRC2_HUMAN | Baculoviral IAP repeat-containing protein 2 (cIAP1) | Cellular inhibitor of apoptosis 1 | Inhibitor of apoptosis protein 2 (cIAP1) | MIHB | RNF48 |
Type: | Protein |
Mol. Mass.: | 69900.47 |
Organism: | Homo sapiens (Human) |
Description: | Q13490 |
Residue: | 618 |
Sequence: | MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGV
PVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSAS
LGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYA
MSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEH
RRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGR
NDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLL
STSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTT
GENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILD
NLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLF
VDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLR
KCPICRGIIKGTVRTFLS
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BDBM156012 |
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n/a |
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Name | BDBM156012 |
Synonyms: | US9018214, 63 |
Type | Small organic molecule |
Emp. Form. | C25H34N4O2 |
Mol. Mass. | 422.5631 |
SMILES | COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3ccccc3)cc12 |r| |
Structure |
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