Reaction Details |
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Target | Tyrosine-protein kinase Blk |
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Ligand | BDBM50109532 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1509369 (CHEMBL3603312) |
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IC50 | 157±n/a nM |
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Citation | Tan, L; Akahane, K; McNally, R; Reyskens, KM; Ficarro, SB; Liu, S; Herter-Sprie, GS; Koyama, S; Pattison, MJ; Labella, K; Johannessen, L; Akbay, EA; Wong, KK; Frank, DA; Marto, JA; Look, TA; Arthur, JS; Eck, MJ; Gray, NS Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem58:6589-606 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Blk |
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Name: | Tyrosine-protein kinase Blk |
Synonyms: | B lymphoid tyrosine kinase | BLK | BLK_HUMAN | SRC | Tyrosine-protein kinase BLK (BLK) | p55-Blk |
Type: | Protein |
Mol. Mass.: | 57711.88 |
Organism: | Homo sapiens (Human) |
Description: | P51451 |
Residue: | 505 |
Sequence: | MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK
HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE
MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR
CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS
LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY
AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD
LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS
FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER
PTFEFLQSVLEDFYTATERQYELQP
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BDBM50109532 |
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n/a |
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Name | BDBM50109532 |
Synonyms: | CHEMBL3601223 |
Type | Small organic molecule |
Emp. Form. | C26H30ClN7O2 |
Mol. Mass. | 508.015 |
SMILES | COc1cc(ccc1Nc1ncc(Cl)c(NCc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1 |
Structure |
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