| Reaction Details |
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 | Report a problem with these data |
| Target | 2-acylglycerol O-acyltransferase 2 |
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| Ligand | BDBM159695 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1510039 (CHEMBL3606131) |
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| IC50 | 147±n/a nM |
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| Citation |  Busujima, T; Tanaka, H; Shirasaki, Y; Munetomo, E; Saito, M; Kitano, K; Minagawa, T; Yoshida, K; Osaki, N; Sato, N Identification of 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide (29) as an orally available MGAT2 inhibitor. Bioorg Med Chem23:5922-31 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 2-acylglycerol O-acyltransferase 2 |
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| Name: | 2-acylglycerol O-acyltransferase 2 |
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| Synonyms: | 2-acylglycerol O-acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 (MOGAT2) | DC5 | DGAT2L5 | Diacylglycerol O-acyltransferase candidate 5 | Diacylglycerol acyltransferase 2-like protein 5 | MGAT2 | MOGAT2 | MOGT2_HUMAN | Monoacylglycerol Acyltransferase 2 (MGAT2) | Monoacylglycerol O-acyltransferase 2 | hDC5 | hMGAT2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 38210.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q3SYC2 |
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| Residue: | 334 |
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| Sequence: | MVEFAPLFMPWERRLQTLAVLQFVFSFLALAEICTVGFIALLFTRFWLLTVLYAAWWYLD
RDKPRQGGRHIQAIRCWTIWKYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAVGAFAN
LCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGLVTSEKESAAHILNRKGGGNL
LGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGAPLVPIFSFGENDLFDQIPNSSG
SWLRYIQNRLQKIMGISLPLFHGRGVFQYSFGLIPYRRPITTVVGKPIEVQKTLHPSEEE
VNQLHQRYIKELCNLFEAHKLKFNIPADQHLEFC
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| BDBM159695 |
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| n/a |
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| Name | BDBM159695 |
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| Synonyms: | US9035059, 14-18 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H36FN3O4S |
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| Mol. Mass. | 553.688 |
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| SMILES | CCCCCOc1ccc(NS(=O)(=O)c2ccc3CN(Cc3c2)C(=O)Nc2ccc(cc2)C(C)(C)C)c(F)c1 |
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| Structure | 
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