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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50110733 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1510389 (CHEMBL3607229) | ||
| IC50 | 63±n/a nM | ||
| Citation |  Luz, JG; Carson, MW; Condon, B; Clawson, D; Pustilnik, A; Kohlman, DT; Barr, RJ; Bean, JS; Dill, MJ; Sindelar, DK; Maletic, M; Coghlan, MJ Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site. J Med Chem58:6607-18 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_RAT | Glucocorticoid | Glucocorticoid Receptor (GR) | Glucocorticoid receptor | Grl | Nr3c1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 87556.83 | ||
| Organism: | RAT | ||
| Description: | Glucocorticoid 0 RAT::P06536 | ||
| Residue: | 795 | ||
| Sequence: |
| ||
| BDBM50110733 | |||
| n/a | |||
| Name | BDBM50110733 | ||
| Synonyms: | CHEMBL3605929 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H16F2N2O3S | ||
| Mol. Mass. | 366.382 | ||
| SMILES | COc1cc(F)ccc1-c1c(C)[nH]c2c(NS(C)(=O)=O)cc(F)cc12 |(-1,4.66,;-.24,3.69,;1.29,3.91,;1.86,5.34,;3.38,5.55,;3.84,6.7,;4.33,4.34,;3.76,2.91,;2.23,2.7,;1.76,1.24,;2.66,.02,;3.89,.03,;1.76,-1.24,;.3,-.77,;-1.03,-1.55,;-1.02,-3.09,;-2.35,-3.87,;-3.42,-3.26,;-2.35,-5.1,;-3.42,-4.49,;-2.38,-.77,;-2.38,.77,;-3.45,1.38,;-1.03,1.55,;.3,.77,)| | ||
| Structure | 
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