| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 26 |
|---|
| Ligand | BDBM138348 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1510631 (CHEMBL3607979) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Papeo, G; Posteri, H; Borghi, D; Busel, AA; Caprera, F; Casale, E; Ciomei, M; Cirla, A; Corti, E; D'Anello, M; Fasolini, M; Forte, B; Galvani, A; Isacchi, A; Khvat, A; Krasavin, MY; Lupi, R; Orsini, P; Perego, R; Pesenti, E; Pezzetta, D; Rainoldi, S; Riccardi-Sirtori, F; Scolaro, A; Sola, F; Zuccotto, F; Felder, ER; Donati, D; Montagnoli, A Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy. J Med Chem58:6875-98 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase 26 |
|---|
| Name: | Serine/threonine-protein kinase 26 |
|---|
| Synonyms: | MASK | MST4 | STK26 | STK26_HUMAN | Serine/threonine-protein kinase MST4 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 46517.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1510631 |
|---|
| Residue: | 416 |
|---|
| Sequence: | MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA
EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ
IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV
GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLV
GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS
DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA
FAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
|
|
|
|---|
| BDBM138348 |
|---|
| n/a |
|---|
| Name | BDBM138348 |
|---|
| Synonyms: | US8877944, 99 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H24F3N3O2 |
|---|
| Mol. Mass. | 395.4187 |
|---|
| SMILES | NC(=O)c1cc(F)cc2CN(C3CCN(CC3)C3CCC(F)(F)CC3)C(=O)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
