| Reaction Details |
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 | Report a problem with these data |
| Target | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
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| Ligand | BDBM50111203 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1509932 (CHEMBL3607750) |
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| IC50 | 46±n/a nM |
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| Citation |  Becherer, JD; Boros, EE; Carpenter, TY; Cowan, DJ; Deaton, DN; Haffner, CD; Jeune, MR; Kaldor, IW; Poole, JC; Preugschat, F; Rheault, TR; Schulte, CA; Shearer, BG; Shearer, TW; Shewchuk, LM; Smalley, TL; Stewart, EL; Stuart, JD; Ulrich, JC Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38. J Med Chem58:7021-56 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
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| Name: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
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| Synonyms: | ADP-ribosyl cyclase 1 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | ADPRC 1 | CD38_MOUSE | CD_antigen=CD38 | Cd38 | Cyclic ADP-ribose hydrolase 1 | I-19 | NIM-R5 antigen | cADPr hydrolase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34417.04 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_109609 |
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| Residue: | 304 |
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| Sequence: | MANYEFSQVSGDRPGCRLSRKAQIGLGVGLLVLIALVVGIVVILLRPRSLLVWTGEPTTK
HFSDIFLGRCLIYTQILRPEMRDQNCQEILSTFKGAFVSKNPCNITREDYAPLVKLVTQT
IPCNKTLFWSKSKHLAHQYTWIQGKMFTLEDTLLGYIADDLRWCGDPSTSDMNYVSCPHW
SENCPNNPITVFWKVISQKFAEDACGVVQVMLNGSLREPFYKNSTFGSVEVFSLDPNKVH
KLQAWVMHDIEGASSNACSSSSLNELKMIVQKRNMIFACVDNYRPARFLQCVKNPEHPSC
RLNT
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| BDBM50111203 |
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| n/a |
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| Name | BDBM50111203 |
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| Synonyms: | CHEMBL3604735 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14Cl3N3O |
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| Mol. Mass. | 394.682 |
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| SMILES | Cc1cc(NCc2c(Cl)ccc(Cl)c2Cl)c2cccc(C(N)=O)c2n1 |
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| Structure | 
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