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TargetIsocitrate dehydrogenase [NADP] cytoplasmic
LigandBDBM50111801
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1510683 (CHEMBL3606169)
Ki 4300±n/a nM
Citation Wu, FJiang, HZheng, BKogiso, MYao, YZhou, CLi, XNSong, Y Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. J Med Chem58:6899-908 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Isocitrate dehydrogenase [NADP] cytoplasmic
Name:Isocitrate dehydrogenase [NADP] cytoplasmic
Synonyms:Cytosolic NADP-isocitrate dehydrogenase | IDH | IDH1 | IDHC_HUMAN | IDP | Isocitrate Dehydrogenase (IDH1) | Isocitrate dehydrogenase 1 (IDH1) | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase | PICD
Type:Protein
Mol. Mass.:46661.29
Organism:Homo sapiens (Human)
Description:O75874
Residue:414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
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  Blast E-value cutoff:
BDBM50111801
n/a
NameBDBM50111801
Synonyms:CHEMBL3605389
TypeSmall organic molecule
Emp. Form.C11H11N3O3S
Mol. Mass.265.288
SMILESCOc1ccc(\C=C2\NC(=S)N(C)C2=O)c[n+]1[O-]
Structure
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