| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 1 |
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| Ligand | BDBM50112348 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1513224 (CHEMBL3610932) |
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| IC50 | 5.2±n/a nM |
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| Citation |  Karpov, AS; Amiri, P; Bellamacina, C; Bellance, MH; Breitenstein, W; Daniel, D; Denay, R; Fabbro, D; Fernandez, C; Galuba, I; Guerro-Lagasse, S; Gutmann, S; Hinh, L; Jahnke, W; Klopp, J; Lai, A; Lindvall, MK; Ma, S; Möbitz, H; Pecchi, S; Rummel, G; Shoemaker, K; Trappe, J; Voliva, C; Cowan-Jacob, SW; Marzinzik, AL Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett6:776-81 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PAK 1 |
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| Name: | Serine/threonine-protein kinase PAK 1 |
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| Synonyms: | 2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK |
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| Type: | n/a |
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| Mol. Mass.: | 60640.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13153 |
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| Residue: | 545 |
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| Sequence: | MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD
DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE
KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC
MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK
RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG
TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEA
TKNNH
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| BDBM50112348 |
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| n/a |
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| Name | BDBM50112348 |
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| Synonyms: | CHEMBL3609372 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25ClF3N5O |
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| Mol. Mass. | 479.926 |
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| SMILES | CC(C)NC(=O)N1CC[C@@H](C1)NC1=Nc2cc(F)ccc2N(CC(F)F)c2ccc(Cl)cc12 |r,t:13| |
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| Structure | 
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