| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 5 |
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| Ligand | BDBM50112354 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1513396 (CHEMBL3611551) |
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| IC50 | >10000±n/a nM |
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| Citation |  Karpov, AS; Amiri, P; Bellamacina, C; Bellance, MH; Breitenstein, W; Daniel, D; Denay, R; Fabbro, D; Fernandez, C; Galuba, I; Guerro-Lagasse, S; Gutmann, S; Hinh, L; Jahnke, W; Klopp, J; Lai, A; Lindvall, MK; Ma, S; Möbitz, H; Pecchi, S; Rummel, G; Shoemaker, K; Trappe, J; Voliva, C; Cowan-Jacob, SW; Marzinzik, AL Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett6:776-81 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PAK 5 |
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| Name: | Serine/threonine-protein kinase PAK 5 |
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| Synonyms: | KIAA1264 | PAK5 | PAK5_HUMAN | PAK7 | PAK7/PAK5 | Protein Kinase PAK5 | Serine/threonine-protein kinase (PAK7) | Serine/threonine-protein kinase PAK 5 | Serine/threonine-protein kinase PAK7 |
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| Type: | Protein |
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| Mol. Mass.: | 80760.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9P286 |
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| Residue: | 719 |
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| Sequence: | MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT
PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA
EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA
YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA
GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG
ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS
QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS
DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM
DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM
NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR
KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP
PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH
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| BDBM50112354 |
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| n/a |
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| Name | BDBM50112354 |
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| Synonyms: | CHEMBL472940 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14O2S2 |
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| Mol. Mass. | 350.454 |
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| SMILES | Oc1ccc2ccccc2c1SSc1c(O)ccc2ccccc12 |
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| Structure | 
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