Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSerine/threonine-protein kinase PAK 4
LigandBDBM50112347
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1513389 (CHEMBL3611429)
IC50>10000±n/a nM
Citation Karpov, ASAmiri, PBellamacina, CBellance, MHBreitenstein, WDaniel, DDenay, RFabbro, DFernandez, CGaluba, IGuerro-Lagasse, SGutmann, SHinh, LJahnke, WKlopp, JLai, ALindvall, MKMa, SMöbitz, HPecchi, SRummel, GShoemaker, KTrappe, JVoliva, CCowan-Jacob, SWMarzinzik, AL Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett6:776-81 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase PAK 4
Name:Serine/threonine-protein kinase PAK 4
Synonyms:KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4)
Type:Protein
Mol. Mass.:64098.01
Organism:Homo sapiens (Human)
Description:O96013
Residue:591
Sequence:
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50112347
n/a
NameBDBM50112347
Synonyms:CHEMBL3609327 | FRAX597
TypeSmall organic molecule
Emp. Form.C29H28ClN7OS
Mol. Mass.558.097
SMILESCCn1c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2cc(-c2ccc(cc2Cl)-c2cncs2)c1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: