| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM50112586 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1513553 (CHEMBL3610010) |
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| IC50 | 5.0±n/a nM |
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| Citation |  Wang, Y; Cai, W; Cheng, Y; Yang, T; Liu, Q; Zhang, G; Meng, Q; Han, F; Huang, Y; Zhou, L; Xiang, Z; Zhao, YG; Xu, Y; Cheng, Z; Lu, S; Wu, Q; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant ROR¿t Inhibitors. ACS Med Chem Lett6:787-92 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM50112586 |
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| n/a |
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| Name | BDBM50112586 |
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| Synonyms: | CHEMBL3609399 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22F3NO4S |
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| Mol. Mass. | 477.496 |
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| SMILES | CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(C)c2)-c2ccccc2OC(F)(F)F)cc1 |
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| Structure | 
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