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TargetDiscoidin domain-containing receptor 2
LigandBDBM50112617
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1513724
IC50 3.3±n/a nM
Citation Murray CWBerdini VBuck IMCarr MECleasby ACoyle JECurry JEDay JEDay PJHearn KIqbal ALee LYMartins VMortenson PNMunck JMPage LWPatel SRoomans SSmith KTamanini ESaxty G Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors. ACS Med Chem Lett 6:798-803 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Discoidin domain-containing receptor 2
Name:Discoidin domain-containing receptor 2
Synonyms:Discoidin domain receptor 2 (DDR2) | Discoidin domain-containing receptor 2 (DDR2) | Epithelial discoidin domain-containing receptor 2 (DDR2)
Type:Protein
Mol. Mass.:96717.07
Organism:Homo sapiens (Human)
Description:n/a
Residue:855
Sequence:
MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY
GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI
NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV
ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD
DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK
EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS
EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL
WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD
YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV
PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN
QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG
DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK
NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET
FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP
SFQEIHLLLLQQGDE
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  Blast E-value cutoff:
BDBM50112617
n/a
NameBDBM50112617
Synonyms:CHEMBL3608786
TypeSmall organic molecule
Emp. Form.C23H20FN5O2
Mol. Mass.417.4356
SMILESCc1ccc(CNC(=O)Nc2cccc(F)c2)cc1NC(=O)c1cnc2ccccn12
Structure
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