| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 1 |
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| Ligand | BDBM150812 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1513745 (CHEMBL3610855) |
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| IC50 | 31±n/a nM |
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| Citation |  Schuler, AD; Engles, CA; Maeda, DY; Quinn, MT; Kirpotina, LN; Wicomb, WN; Mason, SN; Auten, RL; Zebala, JA Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability. Bioorg Med Chem Lett25:3793-7 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 1 |
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| Name: | C-X-C chemokine receptor type 1 |
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| Synonyms: | C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39803.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25024 |
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| Residue: | 350 |
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| Sequence: | MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
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| BDBM150812 |
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| n/a |
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| Name | BDBM150812 |
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| Synonyms: | US8981106, 2 (SX-576) | USRE47267, Compound 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15BF4N2O4S |
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| Mol. Mass. | 466.214 |
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| SMILES | OB(O)c1ccc(OC(F)(F)F)cc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1 |
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| Structure | 
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