| Reaction Details |
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 | Report a problem with these data |
| Target | Lysophosphatidylserine lipase ABHD12 |
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| Ligand | BDBM24567 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1514755 (CHEMBL3614956) |
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| IC50 | 190±n/a nM |
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| Citation |  Patel, JZ; van Bruchem, J; Laitinen, T; Kaczor, AA; Navia-Paldanius, D; Parkkari, T; Savinainen, JR; Laitinen, JT; Nevalainen, TJ Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors. Bioorg Med Chem23:6335-45 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysophosphatidylserine lipase ABHD12 |
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| Name: | Lysophosphatidylserine lipase ABHD12 |
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| Synonyms: | ABD12_HUMAN | ABHD12 | C20orf22 | Monoacylglycerol lipase ABHD12 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45111.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1514755 |
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| Residue: | 398 |
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| Sequence: | MRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKR
ALGRRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQ
GLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQGKDQMWYEDALASSHPIILYLHGNAGT
RGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPV
YIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWF
FLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQ
FVPFHSDLGYRHKYIYKSPELPRILREFLGKSEPEHQH
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| BDBM24567 |
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| n/a |
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| Name | BDBM24567 |
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| Synonyms: | (2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate | CHEMBL175247 | Orlistat | THLP | Tetrahydrolipstatin | US9328123, Orlistat | Xenical |
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| Type | Small organic molecule |
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| Emp. Form. | C29H53NO5 |
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| Mol. Mass. | 495.7348 |
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| SMILES | CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| |
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| Structure | 
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