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TargetATP-sensitive inward rectifier potassium channel 1
LigandBDBM50442600
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1515513
IC50 64±n/a nM
Citation Walsh SPShahripour ATang HTeumelsan NFrie JZhu YPriest BTSwensen AMLiu JMargulis MVisconti RWeinglass AFelix JPBrochu RMBailey TThomas-Fowlkes BAlonso-Galicia MZhou XPai LYCorona AHampton CHernandez MBentley RChen JShah KMetzger JForrest MOwens KTong VHa SRoy SKaczorowski GJYang LParmee EGarcia MLSullivan KPasternak A Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation. ACS Med Chem Lett 6:747-52 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
ATP-sensitive inward rectifier potassium channel 1
Name:ATP-sensitive inward rectifier potassium channel 1
Synonyms:Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:Enzyme Catalytic Domain
Mol. Mass.:44809.08
Organism:Homo sapiens (Human)
Description:gi_223460826
Residue:391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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BDBM50442600
n/a
NameBDBM50442600
Synonyms:CHEMBL2441437 | US9056859, 1
TypeSmall organic molecule
Emp. Form.C23H24N6O3
Mol. Mass.432.4751
SMILESO=C(Cc1ccc(cc1)-n1cnnn1)N1CCN(CCc2ccc3C(=O)OCc3c2)CC1
Structure
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