Reaction Details |
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Target | Inward rectifier potassium channel 4 |
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Ligand | BDBM155928 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1515519 (CHEMBL3615700) |
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IC50 | >50000±n/a nM |
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Citation | Walsh, SP; Shahripour, A; Tang, H; Teumelsan, N; Frie, J; Zhu, Y; Priest, BT; Swensen, AM; Liu, J; Margulis, M; Visconti, R; Weinglass, A; Felix, JP; Brochu, RM; Bailey, T; Thomas-Fowlkes, B; Alonso-Galicia, M; Zhou, X; Pai, LY; Corona, A; Hampton, C; Hernandez, M; Bentley, R; Chen, J; Shah, K; Metzger, J; Forrest, M; Owens, K; Tong, V; Ha, S; Roy, S; Kaczorowski, GJ; Yang, L; Parmee, E; Garcia, ML; Sullivan, K; Pasternak, A Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation. ACS Med Chem Lett6:747-52 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Inward rectifier potassium channel 4 |
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Name: | Inward rectifier potassium channel 4 |
Synonyms: | HIR | HIRK2 | HRK1 | Hippocampal inward rectifier | IRK-3 | IRK3 | Inward rectifier K(+) channel Kir2.3 | KCNJ4 | KCNJ4_HUMAN | Potassium channel, inwardly rectifying subfamily J member 4 |
Type: | PROTEIN |
Mol. Mass.: | 49496.50 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1515519 |
Residue: | 445 |
Sequence: | MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLM
IFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNG
FLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKK
RAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQR
DLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMT
TQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITV
LPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFG
SHLDLERMQASLPLDNISYRRESAI
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BDBM155928 |
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n/a |
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Name | BDBM155928 |
Synonyms: | US9018211, 52 |
Type | Small organic molecule |
Emp. Form. | C24H28N4O5 |
Mol. Mass. | 452.5029 |
SMILES | COc1cc(ncc1C#N)[C@@H](O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1 |r| |
Structure |
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