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TargetInward rectifier potassium channel 4
LigandBDBM155928
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1515519 (CHEMBL3615700)
IC50>50000±n/a nM
Citation Walsh, SPShahripour, ATang, HTeumelsan, NFrie, JZhu, YPriest, BTSwensen, AMLiu, JMargulis, MVisconti, RWeinglass, AFelix, JPBrochu, RMBailey, TThomas-Fowlkes, BAlonso-Galicia, MZhou, XPai, LYCorona, AHampton, CHernandez, MBentley, RChen, JShah, KMetzger, JForrest, MOwens, KTong, VHa, SRoy, SKaczorowski, GJYang, LParmee, EGarcia, MLSullivan, KPasternak, A Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation. ACS Med Chem Lett6:747-52 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Inward rectifier potassium channel 4
Name:Inward rectifier potassium channel 4
Synonyms:HIR | HIRK2 | HRK1 | Hippocampal inward rectifier | IRK-3 | IRK3 | Inward rectifier K(+) channel Kir2.3 | KCNJ4 | KCNJ4_HUMAN | Potassium channel, inwardly rectifying subfamily J member 4
Type:PROTEIN
Mol. Mass.:49496.50
Organism:Homo sapiens (Human)
Description:ChEMBL_1515519
Residue:445
Sequence:
MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLM
IFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNG
FLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKK
RAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQR
DLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMT
TQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITV
LPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFG
SHLDLERMQASLPLDNISYRRESAI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM155928
n/a
NameBDBM155928
Synonyms:US9018211, 52
TypeSmall organic molecule
Emp. Form.C24H28N4O5
Mol. Mass.452.5029
SMILESCOc1cc(ncc1C#N)[C@@H](O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1 |r|
Structure
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