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TargetATP-sensitive inward rectifier potassium channel 10
LigandBDBM155928
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1515521 (CHEMBL3615702)
IC50>10000±n/a nM
Citation Walsh, SPShahripour, ATang, HTeumelsan, NFrie, JZhu, YPriest, BTSwensen, AMLiu, JMargulis, MVisconti, RWeinglass, AFelix, JPBrochu, RMBailey, TThomas-Fowlkes, BAlonso-Galicia, MZhou, XPai, LYCorona, AHampton, CHernandez, MBentley, RChen, JShah, KMetzger, JForrest, MOwens, KTong, VHa, SRoy, SKaczorowski, GJYang, LParmee, EGarcia, MLSullivan, KPasternak, A Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation. ACS Med Chem Lett6:747-52 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
ATP-sensitive inward rectifier potassium channel 10
Name:ATP-sensitive inward rectifier potassium channel 10
Synonyms:ATP-dependent inwardly rectifying potassium channel Kir4.1 | Inward rectifier K(+) channel Kir1.2 | KCJ10_HUMAN | KCNJ10 | Potassium channel, inwardly rectifying subfamily J member 10
Type:PROTEIN
Mol. Mass.:42513.64
Organism:Homo sapiens (Human)
Description:ChEMBL_105175
Residue:379
Sequence:
MTSVAKVYYSQTTQTESRPLMGPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFI
DMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELDPPANHTPCVVQVHTLTGAFL
FSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIR
FSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQV
DTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSY
LPEEILWGYEFTPAISLSASGKYIADFSLFDQVVKVASPSGLRDSTVRYGDPEKLKLEES
LREQAEKEGSALSVRISNV
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  Blast E-value cutoff:
BDBM155928
n/a
NameBDBM155928
Synonyms:US9018211, 52
TypeSmall organic molecule
Emp. Form.C24H28N4O5
Mol. Mass.452.5029
SMILESCOc1cc(ncc1C#N)[C@@H](O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1 |r|
Structure
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