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TargetATP-sensitive inward rectifier potassium channel 1
LigandBDBM50116799
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1515501
IC50 16±n/a nM
Citation Walsh SPShahripour ATang HTeumelsan NFrie JZhu YPriest BTSwensen AMLiu JMargulis MVisconti RWeinglass AFelix JPBrochu RMBailey TThomas-Fowlkes BAlonso-Galicia MZhou XPai LYCorona AHampton CHernandez MBentley RChen JShah KMetzger JForrest MOwens KTong VHa SRoy SKaczorowski GJYang LParmee EGarcia MLSullivan KPasternak A Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation. ACS Med Chem Lett 6:747-52 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
ATP-sensitive inward rectifier potassium channel 1
Name:ATP-sensitive inward rectifier potassium channel 1
Synonyms:Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:Enzyme Catalytic Domain
Mol. Mass.:44809.08
Organism:Homo sapiens (Human)
Description:gi_223460826
Residue:391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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  Blast E-value cutoff:
BDBM50116799
n/a
NameBDBM50116799
Synonyms:CHEMBL3612928
TypeSmall organic molecule
Emp. Form.C24H28N4O5
Mol. Mass.455.5214
SMILES[2H]C([2H])([2H])Oc1cc(ncc1C#N)C(O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1 |r|
Structure
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