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TargetATP-sensitive inward rectifier potassium channel 1
LigandBDBM50116826
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1515501 (CHEMBL3615682)
IC50 120±n/a nM
Citation Walsh, SPShahripour, ATang, HTeumelsan, NFrie, JZhu, YPriest, BTSwensen, AMLiu, JMargulis, MVisconti, RWeinglass, AFelix, JPBrochu, RMBailey, TThomas-Fowlkes, BAlonso-Galicia, MZhou, XPai, LYCorona, AHampton, CHernandez, MBentley, RChen, JShah, KMetzger, JForrest, MOwens, KTong, VHa, SRoy, SKaczorowski, GJYang, LParmee, EGarcia, MLSullivan, KPasternak, A Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation. ACS Med Chem Lett6:747-52 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
ATP-sensitive inward rectifier potassium channel 1
Name:ATP-sensitive inward rectifier potassium channel 1
Synonyms:ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:Enzyme Catalytic Domain
Mol. Mass.:44809.08
Organism:Homo sapiens (Human)
Description:gi_223460826
Residue:391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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  Blast E-value cutoff:
BDBM50116826
n/a
NameBDBM50116826
Synonyms:CHEMBL3612799
TypeSmall organic molecule
Emp. Form.C25H29N3O4
Mol. Mass.435.5155
SMILESCOc1cc(CCN2CCN(CC(O)c3ccc4C(=O)OCc4c3C)CC2)ccc1C#N
Structure
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