| Reaction Details |
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 | Report a problem with these data |
| Target | Cruzipain |
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| Ligand | BDBM50117285 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1514259 (CHEMBL3614916) |
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| IC50 | 70±n/a nM |
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| Citation |  Espíndola, JW; Cardoso, MV; Filho, GB; Oliveira E Silva, DA; Moreira, DR; Bastos, TM; Simone, CA; Soares, MB; Villela, FS; Ferreira, RS; Castro, MC; Pereira, VR; Murta, SM; Sales Junior, PA; Romanha, AJ; Leite, AC Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain. Eur J Med Chem101:818-35 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cruzipain |
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| Name: | Cruzipain |
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| Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
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| Type: | Protein |
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| Mol. Mass.: | 49831.41 |
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| Organism: | Trypanosoma cruzi |
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| Description: | P25779 |
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| Residue: | 467 |
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| Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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| BDBM50117285 |
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| n/a |
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| Name | BDBM50117285 |
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| Synonyms: | CHEMBL3613583 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12BrClFN3OS |
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| Mol. Mass. | 416.696 |
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| SMILES | NC(=S)N\N=C(/COc1ccc(F)c(Cl)c1)c1ccc(Br)cc1 |
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| Structure | 
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