| Reaction Details |
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 | Report a problem with these data |
| Target | LIM domain kinase 1 |
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| Ligand | BDBM50117627 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1514397 (CHEMBL3615476) |
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| IC50 | 31±n/a nM |
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| Citation |  Boland, S; Bourin, A; Alen, J; Geraets, J; Schroeders, P; Castermans, K; Kindt, N; Boumans, N; Panitti, L; Vanormelingen, J; Fransen, S; Van de Velde, S; Defert, O Design, synthesis and biological characterization of selective LIMK inhibitors. Bioorg Med Chem Lett25:4005-10 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| LIM domain kinase 1 |
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| Name: | LIM domain kinase 1 |
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| Synonyms: | LIMK | LIMK-1 | LIMK1 | LIMK1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 72591.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_4505001 |
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| Residue: | 647 |
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| Sequence: | MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
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| BDBM50117627 |
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| n/a |
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| Name | BDBM50117627 |
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| Synonyms: | CHEMBL3613614 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N6O3 |
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| Mol. Mass. | 394.4271 |
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| SMILES | COC(=O)c1cccc(NC(=O)C2(N)CCN(CC2)c2ncnc3[nH]ccc23)c1 |
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| Structure | 
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