| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 4 |
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| Ligand | BDBM50117636 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1514431 (CHEMBL3615627) |
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| IC50 | 57±n/a nM |
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| Citation |  Wei, ZL; Nguyen, MT; O'Mahony, DJ; Acevedo, A; Zipfel, S; Zhang, Q; Liu, L; Dourado, M; Chi, C; Yip, V; DeFalco, J; Gustafson, A; Emerling, DE; Kelly, MG; Kincaid, J; Vincent, F; Duncton, MA Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg Med Chem Lett25:4011-5 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential cation channel subfamily V member 4 |
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| Name: | Transient receptor potential cation channel subfamily V member 4 |
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| Synonyms: | TRPV4_MOUSE | Trp12 | Trpv4 | Vrl2 | Vroac |
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| Type: | PROTEIN |
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| Mol. Mass.: | 98032.61 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1514430 |
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| Residue: | 871 |
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| Sequence: | MADPGDGPRAAPGEVAEPPGDESGTSGGEAFPLSSLANLFEGEEGSSSLSPVDASRPAGP
GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDN
KRWRRKVVEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLSFLLTHKKRL
TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT
SLHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI
VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCSRLFPDS
NLETVLNNDGLSPLMMAAKTGKIGVFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYD
LSSLDTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLC
AMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTSIKDLFTKKCPGV
NSLFVDGSFQLLYFIYSVLVVVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTG
TYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCDEDQSNCTVPTYPAC
RDSETFSAFLLDLFKLTIGMGDLEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGE
TVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV
DEVNWSHWNQNLGIINEDPGKSEIYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSSADE
VVVPLDNLGNPNCDGHQQGYAPKWRTDDAPL
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| BDBM50117636 |
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| n/a |
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| Name | BDBM50117636 |
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| Synonyms: | CHEMBL3613642 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23F3N4O5S |
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| Mol. Mass. | 500.491 |
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| SMILES | CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1 |
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| Structure | 
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