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TargetMenin
LigandBDBM50117743
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1515211
IC50 674±n/a nM
Citation Pollock JBorkin DLund GPurohit TDyguda-Kazimierowicz EGrembecka JCierpicki T Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J Med Chem 58:7465-74 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Menin
Name:Menin
Synonyms:MEN1 | SCG2
Type:Protein
Mol. Mass.:68022.55
Organism:Homo sapiens (Human)
Description:O00255
Residue:615
Sequence:
MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGWSPVGTKLDSSGVAFAVVGACQALGLRDVHL
ALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKME
VAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGR
PDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCR
EDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLR
FYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEA
REGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTA
QVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTP
SDYTLSFLKRQRKGL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50117743
n/a
NameBDBM50117743
Synonyms:CHEMBL3613790
TypeSmall organic molecule
Emp. Form.C17H18F5N5S2
Mol. Mass.451.48
SMILESCC1(C)CN=C(S1)N1CCN(CC1)c1ncnc2sc(cc12)C(F)(F)C(F)(F)F |c:4|
Structure
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