Reaction Details |
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Target | Menin |
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Ligand | BDBM50117749 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1515211 (CHEMBL3614558) |
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IC50 | 92±n/a nM |
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Citation | Pollock, J; Borkin, D; Lund, G; Purohit, T; Dyguda-Kazimierowicz, E; Grembecka, J; Cierpicki, T Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J Med Chem58:7465-74 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Menin |
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Name: | Menin |
Synonyms: | MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2 |
Type: | Protein |
Mol. Mass.: | 68022.55 |
Organism: | Homo sapiens (Human) |
Description: | O00255 |
Residue: | 615 |
Sequence: | MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGWSPVGTKLDSSGVAFAVVGACQALGLRDVHL
ALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKME
VAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGR
PDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCR
EDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLR
FYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEA
REGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTA
QVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTP
SDYTLSFLKRQRKGL
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BDBM50117749 |
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n/a |
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Name | BDBM50117749 |
Synonyms: | CHEMBL3613784 |
Type | Small organic molecule |
Emp. Form. | C15H12F6N6S2 |
Mol. Mass. | 454.416 |
SMILES | FC(F)(F)Cc1cc2c(ncnc2s1)N1CCN(CC1)c1nnc(s1)C(F)(F)F |
Structure |
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