| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Ligand | BDBM50117830 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1515854 (CHEMBL3614717) |
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| Kd | 13000±n/a nM |
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| Citation |  He, W; Zhou, B; Liu, W; Zhang, M; Shen, Z; Han, Z; Jiang, Q; Yang, Q; Song, C; Wang, R; Niu, T; Han, S; Zhang, L; Wu, J; Guo, F; Zhao, R; Yu, W; Chai, J; Chang, J Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO). J Med Chem58:7341-8 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Name: | Alpha-ketoglutarate-dependent dioxygenase FTO |
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| Synonyms: | FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58263.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1515854 |
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| Residue: | 505 |
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| Sequence: | MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEE
LHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPV
KGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVG
MGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRS
AVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDD
LNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFE
PAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHE
VKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDD
ASMPLPFDLTDIVSELRGQLLEAKP
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| BDBM50117830 |
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| n/a |
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| Name | BDBM50117830 |
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| Synonyms: | CHEMBL3613953 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16ClNO3 |
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| Mol. Mass. | 317.767 |
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| SMILES | Oc1cc(O)c(NC(=O)C2(CCC2)c2ccccc2)cc1Cl |
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| Structure | 
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