Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50030618 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1516092 (CHEMBL3615735) |
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Ki | 6.8±n/a nM |
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Citation | Bragagni, M; Bozdag, M; Carta, F; Scozzafava, A; Lanzi, C; Masini, E; Mura, P; Supuran, CT Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents. Bioorg Med Chem23:6223-7 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50030618 |
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n/a |
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Name | BDBM50030618 |
Synonyms: | CHEMBL3354135 |
Type | Small organic molecule |
Emp. Form. | C15H16FN3O5S2 |
Mol. Mass. | 401.433 |
SMILES | NS(=O)(=O)c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(F)cc2)cc1 |
Structure |
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