| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 7 |
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| Ligand | BDBM50118345 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1514893 (CHEMBL3615644) |
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| IC50 | 1680±n/a nM |
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| Citation |  Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9. Bioorg Med Chem23:6280-96 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 7 |
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| Name: | Cyclin-dependent kinase 7 |
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| Synonyms: | 39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 39047.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 346 |
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| Sequence: | MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
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| BDBM50118345 |
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| n/a |
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| Name | BDBM50118345 |
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| Synonyms: | CHEMBL3612514 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11ClN6O4S |
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| Mol. Mass. | 418.814 |
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| SMILES | Cc1ccc(cc1S(=O)(=O)n1cc(cn1)-c1cnn2ccc(Cl)nc12)[N+]([O-])=O |
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| Structure | 
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