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TargetBranched-chain-amino-acid aminotransferase, mitochondrial
LigandBDBM50118588
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1516909 (CHEMBL3618962)
IC50 25±n/a nM
Citation Bertrand, SMAncellin, NBeaufils, BBingham, RPBorthwick, JABoullay, ABBoursier, ECarter, PSChung, CWChurcher, IDodic, NFouchet, MHFournier, CFrancis, PLGummer, LAHerry, KHobbs, AHobbs, CIHomes, PJamieson, CNicodeme, EPickett, SDReid, IHSimpson, GLSloan, LASmith, SESomers, DOSpitzfaden, CSuckling, CJValko, KWashio, YYoung, RJ The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits. J Med Chem58:7140-63 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Branched-chain-amino-acid aminotransferase, mitochondrial
Name:Branched-chain-amino-acid aminotransferase, mitochondrial
Synonyms:BCAT(m) | BCAT2 | BCAT2_HUMAN | BCATM | BCATM | BCT2 | Branched-chain-amino-acid aminotransferase, mitochondrial | ECA40 | PP18 | Placental protein 18
Type:PROTEIN
Mol. Mass.:44297.81
Organism:Homo sapiens (Human)
Description:ChEMBL_109874
Residue:392
Sequence:
MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
TMENGPELILRFQKELKEIQYGIRAHEWMFPV
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  Blast E-value cutoff:
BDBM50118588
n/a
NameBDBM50118588
Synonyms:CHEMBL3617095
TypeSmall organic molecule
Emp. Form.C17H16BrN5O
Mol. Mass.386.246
SMILESCCCc1cc(=O)n2nc(NCc3ccc(Br)cc3)c(C#N)c2[nH]1
Structure
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