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TargetProteasome subunit beta type-5
LigandBDBM50119295
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1515347 (CHEMBL3615140)
Ki 7575±n/a nM
Citation Totaro, KABarthelme, DSimpson, PTSauer, RTSello, JK Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines. Bioorg Med Chem23:6218-22 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Proteasome subunit beta type-5
Name:Proteasome subunit beta type-5
Synonyms:20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:Protein
Mol. Mass.:28480.96
Organism:Homo sapiens (Human)
Description:n/a
Residue:263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
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  Blast E-value cutoff:
BDBM50119295
n/a
NameBDBM50119295
Synonyms:CHEMBL3613815
TypeSmall organic molecule
Emp. Form.C30H42F3N5O6
Mol. Mass.625.6796
SMILESCOC(=O)[C@@H](NC(=O)N[C@@H](C(C)C)C(=O)N[C@H]1CCCCNC(=O)\C=C\[C@H](Cc2cccc(c2)C(F)(F)F)NC1=O)C(C)C |r,t:24|
Structure
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