| Reaction Details |
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 | Report a problem with these data |
| Target | Glucagon receptor |
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| Ligand | BDBM50120372 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1518284 (CHEMBL3620259) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Lin, S; Zhang, F; Jiang, G; Qureshi, SA; Yang, X; Chicchi, GG; Tota, L; Bansal, A; Brady, E; Trujillo, M; Salituro, G; Miller, C; Tata, JR; Zhang, BB; Parmee, ER A novel series of indazole-/indole-based glucagon receptor antagonists. Bioorg Med Chem Lett25:4143-7 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucagon receptor |
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| Name: | Glucagon receptor |
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| Synonyms: | GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54026.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47871 |
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| Residue: | 477 |
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| Sequence: | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
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| BDBM50120372 |
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| n/a |
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| Name | BDBM50120372 |
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| Synonyms: | CHEMBL3616699 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H34F3N3O4 |
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| Mol. Mass. | 629.6681 |
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| SMILES | COc1ccc(cc1-c1nn(C(C(C)C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(C)cc1)C(F)(F)F |
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| Structure | 
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