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TargetMelanin-concentrating hormone receptor 1
LigandBDBM50120787
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1518193 (CHEMBL3619840)
Ki 7.9±n/a nM
Citation Devasthale, PWang, WMignone, JRenduchintala, KRadhakrishnan, SDhanapal, JSelvaraj, JKuppusamy, RPelleymounter, MALonghi, DHuang, NFlynn, NAzzara, AVRohrbach, KDevenny, JRooney, SThomas, MGlick, SGodonis, HHarvey, SCullen, MJZhang, HCaporuscio, CStetsko, PGrubb, MHuang, CZhang, LFreeden, CMurphy, BJRobl, JAWashburn, WN Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies. Bioorg Med Chem Lett25:4412-8 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanin-concentrating hormone receptor 1
Name:Melanin-concentrating hormone receptor 1
Synonyms:G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein
Type:Enzyme Catalytic Domain
Mol. Mass.:39075.64
Organism:RAT
Description:Melanin Concentrating Hormone 1 GPR24 RAT::P97639
Residue:353
Sequence:
MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNST
VIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLIT
AMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWL
YARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVA
PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLG
YANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50120787
n/a
NameBDBM50120787
Synonyms:CHEMBL3618348
TypeSmall organic molecule
Emp. Form.C22H18ClF2N5O4
Mol. Mass.489.859
SMILESCOc1cc(ccc1OCC1(O)CC(F)(F)C1)-n1cnn2cc(cc2c1=O)-c1ncc(Cl)cn1
Structure
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