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TargetPotassium voltage-gated channel subfamily KQT member 4
LigandBDBM50121051
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1520985 (CHEMBL3624289)
EC50 625±n/a nM
Citation Davoren, JEClaffey, MMSnow, SLReese, MRArora, GButler, CRBoscoe, BPChenard, LDeNinno, SLDrozda, SEDuplantier, AJMoine, LRogers, BNRong, SSchuyten, KWright, ASZhang, LSerpa, KAWeber, MLStolyar, PWhisman, TLBaker, KTse, KClark, AJRong, HMather, RJLowe, JA Discovery of a novel Kv7 channel opener as a treatment for epilepsy. Bioorg Med Chem Lett25:4941-4 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Potassium voltage-gated channel subfamily KQT member 4
Name:Potassium voltage-gated channel subfamily KQT member 4
Synonyms:KCNQ (Kv7) potassium channel | KCNQ4 | KCNQ4_HUMAN | KQT-like 4 | Potassium channel subunit alpha KvLQT4 | Potassium voltage-gated channel subfamily KQT member 4 | Voltage-gated potassium channel subunit Kv7.4
Type:PROTEIN
Mol. Mass.:77131.10
Organism:Homo sapiens (Human)
Description:ChEMBL_1520985
Residue:695
Sequence:
MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPG
PGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLST
IQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFI
VFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELIT
AWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLA
AGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRA
YLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHR
PGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQ
KSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRIL
KFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKG
DKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLF
DPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
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  Blast E-value cutoff:
BDBM50121051
n/a
NameBDBM50121051
Synonyms:CHEMBL3621437
TypeSmall organic molecule
Emp. Form.C18H30N4O4
Mol. Mass.366.4552
SMILESCOC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1
Structure
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