| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily KQT member 4 |
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| Ligand | BDBM50121051 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1520990 (CHEMBL3624294) |
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| EC50 | 376±n/a nM |
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| Citation |  Davoren, JE; Claffey, MM; Snow, SL; Reese, MR; Arora, G; Butler, CR; Boscoe, BP; Chenard, L; DeNinno, SL; Drozda, SE; Duplantier, AJ; Moine, L; Rogers, BN; Rong, S; Schuyten, K; Wright, AS; Zhang, L; Serpa, KA; Weber, ML; Stolyar, P; Whisman, TL; Baker, K; Tse, K; Clark, AJ; Rong, H; Mather, RJ; Lowe, JA Discovery of a novel Kv7 channel opener as a treatment for epilepsy. Bioorg Med Chem Lett25:4941-4 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily KQT member 4 |
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| Name: | Potassium voltage-gated channel subfamily KQT member 4 |
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| Synonyms: | KCNQ4_RAT | KQT-like 4 | Kcnq4 | Potassium channel subunit alpha KvLQT4 | Potassium voltage-gated channel subfamily KQT member 4 | Voltage-gated potassium channel subunit Kv7.4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 18856.39 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_109898 |
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| Residue: | 168 |
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| Sequence: | DRIRISISQKRTGPSKQHLAPPPIPTSPSSEQVGEASSPSKVQKSWSFNDRTRFRASLRL
KPRCSAEEGPSEEVAEEKSYQCELTVDDVMPAVKTVIRSVRILKFLVAKRKFKETLRPYD
VKDVIEQYSAGHLDMLGRIKSLQARVDQIVGRGPGDRKTREKGDKGPS
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| BDBM50121051 |
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| n/a |
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| Name | BDBM50121051 |
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| Synonyms: | CHEMBL3621437 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H30N4O4 |
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| Mol. Mass. | 366.4552 |
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| SMILES | COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1 |
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| Structure | 
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