| Reaction Details |
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 | Report a problem with these data |
| Target | Ornithine aminotransferase, mitochondrial |
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| Ligand | BDBM50121376 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1522254 (CHEMBL3626483) |
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| Ki | 2.1±n/a nM |
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| Citation |  Zigmond, E; Ben Ya'acov, A; Lee, H; Lichtenstein, Y; Shalev, Z; Smith, Y; Zolotarov, L; Ziv, E; Kalman, R; Le, HV; Lu, H; Silverman, RB; Ilan, Y Suppression of Hepatocellular Carcinoma by Inhibition of Overexpressed Ornithine Aminotransferase. ACS Med Chem Lett6:840-4 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ornithine aminotransferase, mitochondrial |
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| Name: | Ornithine aminotransferase, mitochondrial |
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| Synonyms: | OAT | OAT_HUMAN | Ornithine aminotransferase, hepatic form | Ornithine aminotransferase, mitochondrial | Ornithine aminotransferase, renal form | Ornithine delta-aminotransferase | Ornithine--oxo-acid aminotransferase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48537.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_102740 |
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| Residue: | 439 |
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| Sequence: | MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPV
ALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVL
GEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGR
TLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVV
PDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYP
VSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNEL
MKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVI
KEDELRESIEIINKTILSF
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| BDBM50121376 |
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| n/a |
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| Name | BDBM50121376 |
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| Synonyms: | GABACULINE |
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| Type | Small organic molecule |
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| Emp. Form. | C7H11NO2 |
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| Mol. Mass. | 141.1677 |
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| SMILES | N[C@@H]1CCCC(=C1)C(O)=O |r,c:5| |
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| Structure | 
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