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TargetFlap endonuclease 1
LigandBDBM50121867
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1517026 (CHEMBL3619485)
IC50 230±n/a nM
Citation Chapman, TMWallace, CGillen, KJBakrania, PKhurana, PCoombs, PJFox, SBureau, EABrownlees, JMelton, DWSaxty, B N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett25:4104-8 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Flap endonuclease 1
Name:Flap endonuclease 1
Synonyms:DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:PROTEIN
Mol. Mass.:42602.57
Organism:Homo sapiens (Human)
Description:ChEMBL_1517026
Residue:380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50121867
n/a
NameBDBM50121867
Synonyms:CHEMBL3617197
TypeSmall organic molecule
Emp. Form.C14H11N3O3
Mol. Mass.269.2554
SMILESOn1c(=O)[nH]c2cc(Nc3ccccc3)ccc2c1=O
Structure
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