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TargetFlap endonuclease 1
LigandBDBM33412
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1517026
IC50 300±n/a nM
Citation Chapman TMWallace CGillen KJBakrania PKhurana PCoombs PJFox SBureau EABrownlees JMelton DWSaxty B N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett 25:4104-8 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Flap endonuclease 1
Name:Flap endonuclease 1
Synonyms:DNase IV | FEN-1 | FEN1 | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:PROTEIN
Mol. Mass.:42602.57
Organism:Homo sapiens (Human)
Description:ChEMBL_1517026
Residue:380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
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  Blast E-value cutoff:
BDBM33412
n/a
NameBDBM33412
Synonyms:CHEMBL183852 | N-hydroxy quinazolinedione, 4
TypeSmall organic molecule
Emp. Form.C8H6N2O3
Mol. Mass.178.1448
SMILESOn1c(=O)[nH]c2ccccc2c1=O
Structure
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