| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Flap endonuclease 1 |
|---|
| Ligand | BDBM50157850 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1517026 (CHEMBL3619485) |
|---|
| IC50 | 680±n/a nM |
|---|
| Citation |  Chapman, TM; Wallace, C; Gillen, KJ; Bakrania, P; Khurana, P; Coombs, PJ; Fox, S; Bureau, EA; Brownlees, J; Melton, DW; Saxty, B N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett25:4104-8 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Flap endonuclease 1 |
|---|
| Name: | Flap endonuclease 1 |
|---|
| Synonyms: | DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 42602.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1517026 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
|
|
|
|---|
| BDBM50157850 |
|---|
| n/a |
|---|
| Name | BDBM50157850 |
|---|
| Synonyms: | 3-Hydroxy-1-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione | CHEMBL182974 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H10N2O3S |
|---|
| Mol. Mass. | 274.295 |
|---|
| SMILES | On1c(=O)n(Cc2ccccc2)c2sccc2c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
