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TargetDeoxyribonuclease-1
LigandBDBM50157846
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1517027 (CHEMBL3619486)
IC50>100000±n/a nM
Citation Chapman, TMWallace, CGillen, KJBakrania, PKhurana, PCoombs, PJFox, SBureau, EABrownlees, JMelton, DWSaxty, B N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett25:4104-8 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Deoxyribonuclease-1
Name:Deoxyribonuclease-1
Synonyms:DNAS1_HUMAN | DNASE1 | DNL1 | DNL1 | DNase I | DRNI | Deoxyribonuclease I | Deoxyribonuclease-1 | INN=Dornase alfa
Type:PROTEIN
Mol. Mass.:31422.78
Organism:Homo sapiens (Human)
Description:ChEMBL_109543
Residue:282
Sequence:
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQ
EVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYD
DGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKW
GLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAG
MLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50157846
n/a
NameBDBM50157846
Synonyms:3-Hydroxy-7-p-tolyl-1H-furo[3,2-d]pyrimidine-2,4-dione | CHEMBL182381
TypeSmall organic molecule
Emp. Form.C13H10N2O4
Mol. Mass.258.2295
SMILESCc1ccc(cc1)-c1coc2c1[nH]c(=O)n(O)c2=O
Structure
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