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TargetDeoxyribonuclease-1
LigandBDBM50157850
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1517027
IC50>100000±n/a nM
Citation Chapman TMWallace CGillen KJBakrania PKhurana PCoombs PJFox SBureau EABrownlees JMelton DWSaxty B N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett 25:4104-8 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Deoxyribonuclease-1
Name:Deoxyribonuclease-1
Synonyms:DNASE1 | DNL1 | DNase I | DRNI | Deoxyribonuclease I | Deoxyribonuclease-1 | INN=Dornase alfa
Type:PROTEIN
Mol. Mass.:31422.78
Organism:Homo sapiens (Human)
Description:ChEMBL_109543
Residue:282
Sequence:
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQ
EVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYD
DGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKW
GLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAG
MLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
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  Blast E-value cutoff:
BDBM50157850
n/a
NameBDBM50157850
Synonyms:3-Hydroxy-1-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione | CHEMBL182974
TypeSmall organic molecule
Emp. Form.C13H10N2O3S
Mol. Mass.274.295
SMILESOn1c(=O)n(Cc2ccccc2)c2sccc2c1=O
Structure
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