Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDeoxyribonuclease-1
LigandBDBM50121882
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1517027
IC50 58900±n/a nM
Citation Chapman TMWallace CGillen KJBakrania PKhurana PCoombs PJFox SBureau EABrownlees JMelton DWSaxty B N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett 25:4104-8 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Deoxyribonuclease-1
Name:Deoxyribonuclease-1
Synonyms:DNASE1 | DNL1 | DNase I | DRNI | Deoxyribonuclease I | Deoxyribonuclease-1 | INN=Dornase alfa
Type:PROTEIN
Mol. Mass.:31422.78
Organism:Homo sapiens (Human)
Description:ChEMBL_109543
Residue:282
Sequence:
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQ
EVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYD
DGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKW
GLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAG
MLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50121882
n/a
NameBDBM50121882
Synonyms:CHEMBL3617285
TypeSmall organic molecule
Emp. Form.C15H18N4O4S
Mol. Mass.350.393
SMILESOc1c(nc([nH]c1=O)-c1cccs1)C(=O)NCCN1CCOCC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: