Reaction Details |
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Target | Non-receptor tyrosine-protein kinase TYK2 |
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Ligand | BDBM50122318 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1518842 (CHEMBL3625648) |
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IC50 | 66±n/a nM |
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Citation | Wan, H; Schroeder, GM; Hart, AC; Inghrim, J; Grebinski, J; Tokarski, JS; Lorenzi, MV; You, D; Mcdevitt, T; Penhallow, B; Vuppugalla, R; Zhang, Y; Gu, X; Iyer, R; Lombardo, LJ; Trainor, GL; Ruepp, S; Lippy, J; Blat, Y; Sack, JS; Khan, JA; Stefanski, K; Sleczka, B; Mathur, A; Sun, JH; Wong, MK; Wu, DR; Li, P; Gupta, A; Arunachalam, PN; Pragalathan, B; Narayanan, S; K C, N; Kuppusamy, P; Purandare, AV Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms. ACS Med Chem Lett6:850-5 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Non-receptor tyrosine-protein kinase TYK2 |
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Name: | Non-receptor tyrosine-protein kinase TYK2 |
Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2 |
Type: | Protein |
Mol. Mass.: | 133666.03 |
Organism: | Homo sapiens (Human) |
Description: | P29597 |
Residue: | 1187 |
Sequence: | MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
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BDBM50122318 |
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n/a |
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Name | BDBM50122318 |
Synonyms: | BMS-911543 |
Type | Small organic molecule |
Emp. Form. | C23H28N8O |
Mol. Mass. | 432.5214 |
SMILES | CCn1c(cc2c1nc(Nc1cc(C)n(C)n1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 |
Structure |
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