| Reaction Details |
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 | Report a problem with these data |
| Target | Branched-chain-amino-acid aminotransferase, mitochondrial |
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| Ligand | BDBM50122747 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1520076 (CHEMBL3625417) |
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| IC50 | 15100±n/a nM |
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| Citation |  Deng, H; Zhou, J; Sundersingh, FS; Summerfield, J; Somers, D; Messer, JA; Satz, AL; Ancellin, N; Arico-Muendel, CC; Sargent Bedard, KL; Beljean, A; Belyanskaya, SL; Bingham, R; Smith, SE; Boursier, E; Carter, P; Centrella, PA; Clark, MA; Chung, CW; Davie, CP; Delorey, JL; Ding, Y; Franklin, GJ; Grady, LC; Herry, K; Hobbs, C; Kollmann, CS; Morgan, BA; Pothier Kaushansky, LJ; Zhou, Q Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library. ACS Med Chem Lett6:919-24 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Branched-chain-amino-acid aminotransferase, mitochondrial |
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| Name: | Branched-chain-amino-acid aminotransferase, mitochondrial |
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| Synonyms: | BCAT(m) | BCAT2 | BCAT2_HUMAN | BCATM | BCATM | BCT2 | Branched-chain-amino-acid aminotransferase, mitochondrial | ECA40 | PP18 | Placental protein 18 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44297.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109874 |
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| Residue: | 392 |
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| Sequence: | MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
TMENGPELILRFQKELKEIQYGIRAHEWMFPV
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| BDBM50122747 |
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| n/a |
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| Name | BDBM50122747 |
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| Synonyms: | CHEMBL3623146 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24N4O5S2 |
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| Mol. Mass. | 524.612 |
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| SMILES | CNC(=O)c1ccc(cc1O[C@@H]1CCN(C1)C(=O)c1ccc(s1)C#N)-c1ccccc1NS(C)(=O)=O |r| |
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| Structure | 
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