| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 1 group I member 2 |
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| Ligand | BDBM50122844 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1520094 (CHEMBL3625558) |
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| IC50 | >30000±n/a nM |
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| Citation |  Liu, P; Hu, Z; DuBois, BG; Moyes, CR; Hunter, DN; Zhu, C; Kar, NF; Zhu, Y; Garfunkle, J; Kang, L; Chicchi, G; Ehrhardt, A; Woods, A; Seo, T; Woods, M; van Heek, M; Dingley, KH; Pang, J; Salituro, GM; Powell, J; Terebetski, JL; Hornak, V; Campeau, LC; Lamberson, J; Ujjainwalla, F; Miller, M; Stamford, A; Wood, HB; Kowalski, T; Nargund, RP; Edmondson, SD Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes. ACS Med Chem Lett6:936-41 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 1 group I member 2 |
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| Name: | Nuclear receptor subfamily 1 group I member 2 |
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| Synonyms: | NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 |
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| Type: | Nuclear receptor |
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| Mol. Mass.: | 49774.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75469 |
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| Residue: | 434 |
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| Sequence: | MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
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| BDBM50122844 |
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| n/a |
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| Name | BDBM50122844 |
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| Synonyms: | CHEMBL3622175 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30FN3O4S |
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| Mol. Mass. | 463.565 |
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| SMILES | COCc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1COCc1ccc(cc1F)S(C)(=O)=O |r| |
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| Structure | 
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