Reaction Details |
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Target | Cytochrome P450 2C8 |
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Ligand | BDBM50123453 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1521058 (CHEMBL3624489) |
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IC50 | >50±n/a nM |
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Citation | Zeng, Q; Wang, J; Cheng, Z; Chen, K; Johnström, P; Varnäs, K; Li, DY; Yang, ZF; Zhang, X Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. J Med Chem58:8200-15 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2C8 |
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Name: | Cytochrome P450 2C8 |
Synonyms: | CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase |
Type: | Protein |
Mol. Mass.: | 55839.23 |
Organism: | Homo sapiens (Human) |
Description: | P10632 |
Residue: | 490 |
Sequence: | MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
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BDBM50123453 |
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n/a |
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Name | BDBM50123453 |
Synonyms: | CHEMBL3623290 |
Type | Small organic molecule |
Emp. Form. | C22H23ClFN5O3 |
Mol. Mass. | 459.901 |
SMILES | COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC(=O)N1CCN(C)C[C@H]1C |r| |
Structure |
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