| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase TXK |
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| Ligand | BDBM50123457 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1521549 (CHEMBL3627427) |
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| IC50 | 95±n/a nM |
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| Citation |  Liu, Q; Batt, DG; Lippy, JS; Surti, N; Tebben, AJ; Muckelbauer, JK; Chen, L; An, Y; Chang, C; Pokross, M; Yang, Z; Wang, H; Burke, JR; Carter, PH; Tino, JA Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2). Bioorg Med Chem Lett25:4265-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase TXK |
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| Name: | Tyrosine-protein kinase TXK |
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| Synonyms: | PTK4 | Protein-tyrosine kinase 4 | RLK | Resting lymphocyte kinase | TXK | TXK_HUMAN | Tyrosine-protein kinase TXK (TXK) |
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| Type: | Protein |
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| Mol. Mass.: | 61268.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42681 |
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| Residue: | 527 |
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| Sequence: | MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN
TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW
KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH
LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT
RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA
INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG
KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY
VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS
EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
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| BDBM50123457 |
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| n/a |
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| Name | BDBM50123457 |
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| Synonyms: | CHEMBL3622193 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H33FN6O3 |
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| Mol. Mass. | 592.6626 |
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| SMILES | CN(C)c1ccc(cc1)C(=O)Nc1cccc(c1F)-c1ccc(C(N)=O)c2[nH]c3cc(ccc3c12)C(=O)N1CCN(C)CC1 |
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| Structure | 
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