Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM50123551 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1521543 (CHEMBL3627421) | ||
IC50 | 12±n/a nM | ||
Citation | Liu, Q; Batt, DG; Lippy, JS; Surti, N; Tebben, AJ; Muckelbauer, JK; Chen, L; An, Y; Chang, C; Pokross, M; Yang, Z; Wang, H; Burke, JR; Carter, PH; Tino, JA Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2). Bioorg Med Chem Lett25:4265-9 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM50123551 | |||
n/a | |||
Name | BDBM50123551 | ||
Synonyms: | CHEMBL3621518 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H22F2N4O2 | ||
Mol. Mass. | 448.4646 | ||
SMILES | CN1CCN(CC1)C(=O)c1ccc2c(c1)[nH]c1c(ccc(-c3c(F)cccc3F)c21)C(N)=O |(10.57,1.6,;9.47,.96,;9.48,-.63,;8.1,-1.43,;6.72,-.64,;6.72,.95,;8.09,1.75,;5.34,-1.43,;5.35,-2.71,;3.96,-.64,;3.96,.87,;2.62,1.63,;1.3,.87,;1.3,-.64,;2.62,-1.4,;,-1.4,;-1.3,-.64,;-2.64,-1.4,;-3.92,-.64,;-3.92,.87,;-2.64,1.63,;-2.66,3.22,;-1.29,4.03,;-.18,3.4,;-1.3,5.62,;-2.68,6.41,;-4.05,5.6,;-4.04,4.01,;-5.14,3.36,;-1.3,.87,;-2.68,-2.99,;-1.59,-3.65,;-3.79,-3.6,)| | ||
Structure |