Reaction Details |
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Target | Tyrosine-protein kinase SYK |
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Ligand | BDBM50126443 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1521567 (CHEMBL3627445) |
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IC50 | 951±n/a nM |
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Citation | Thoma, G; Veenstra, S; Strang, R; Blanz, J; Vangrevelinghe, E; Berghausen, J; Lee, CC; Zerwes, HG Orally bioavailable Syk inhibitors with activity in a rat PK/PD model. Bioorg Med Chem Lett25:4642-7 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase SYK |
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Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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BDBM50126443 |
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n/a |
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Name | BDBM50126443 |
Synonyms: | CHEMBL30678 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin-5-yl]-propane-1,3-diamine | N1-(7-(4-(dimethylamino)phenyl)-1,6-naphthyridin-5-yl)propane-1,3-diamine |
Type | Small organic molecule |
Emp. Form. | C19H23N5 |
Mol. Mass. | 321.4194 |
SMILES | CN(C)c1ccc(cc1)-c1cc2ncccc2c(NCCCN)n1 |
Structure |
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